crohn's disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T35664	Tetracosactide acetate		Others
	Cosyntropin (acetate) stimulates the release of corticosteroids such as cortisol from the adrenal gland.		Others
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T4084	Sibofimloc	VRT-1353385,Antibiotic-202,Antibiotic 202	Antibacterial , Antibiotic
	Sibofimloc (Antibiotic-202), an antibiotic compound, is used in treating bacterial infections.		Antibacterial , Antibiotic
T2735	5-Acetylsalicylic acid	5-acetyl-2-hydroxybenzoic acid	Others
	5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) has anti-inflammatory effects and can be used to treat inflammatory bowel disease, including ulcerative colitis, inflamed anus or rectum, and to maintain remission ...		Others
T9914	Vedolizumab		Integrin
	Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.		Integrin
T9921	Infliximab		TNF
	Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.		TNF
T12177	Natalizumab		Integrin
	Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.		Integrin
T5095	Oxazolone	4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one	Others
	Oxazolone has been used as a haptenizing agent, which can induce an inflammatory reaction in adult zebrafish intestinal tissues and this can be used as a model for gene expression studies of the two forms of inflammatory...		Others
T31719	Etiprednol dicloacetate	BNP 166,BNP166,BNP-166	Others
	Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as ...		Others
T6923	Ozanimod	RPC-1063	S1P Receptor , LPL Receptor
	Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero...		S1P Receptor , LPL Receptor
T76741	Eldelumab	BMS-936557,MDX-1100	CXCR
	Eldelumab (BMS-936557) is a humanized anti-IP-10 IgG type 1 monoclonal antibody with inhibitory activity against CXCL10.Eldelumab has anti-inflammatory activity and selectively binds to CXCL10 and can be used in the stud...		CXCR
T27142	Delmitide	Rationally Designed Peptide-58,RDP-1258,RDP5,Allotrap-1258,RDP1258,RDP-5
	Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.
T31058	CP-461 free base	CEL031,CP461,UNII-824ZMS3BGL,CP-461,OSI-461
	CP-461 (OSI-461) is a pde2a / 5A inhibitor, which may be used in the treatment of renal cell carcinoma, prostate cancer, and Crohn's disease.
T81606	Onercept
	Onercept, a recombinant soluble form of the human tumor necrosis factor-alpha (TNF-α) p55 receptor, is utilized in the study of Crohn's disease [1].
T70472	Filgotinib HCl hydrate
	Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease.
T80560	Tulisokibart	PRA-023,PRA023
	Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody that targets TNFSF15/TL1A, with potential applications in researching various inflammatory and fibrotic diseases, including Crohn's Disease (CD) [1] [2].
T77143	Ravagalimab
	Ravagalimab (ABBV-323), a CD40 antagonist with an EC50 of 3.7 nM, is utilized in the research of Crohn's disease [1].
T80559	Duvakitug
	Duvakitug, a humanized IgG1-λ2 monoclonal antibody, targets TNFSF15/TL1A and is primarily expressed in CHOK1SV cells with endogenous glutamine synthetase (GS) activity. It has applications in the research of Crohn's Dise...
T76839	Visilizumab
	Visilizumab, a humanized IgG2 monoclonal antibody with low Fc receptor binding affinity, targets the CD3 epsilon (CD3ε) subunit. It is utilized in research related to ulcerative colitis and Crohn's disease [1].
T74432	Mongersen
	Mongersen (GED-0301), a specific and orally active SMAD7 antisense oligonucleotide, enhances TGF-β1 activity, reducing inflammatory signals. It has been shown to alleviate experimental colitis resembling Crohn's disease ...